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Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs

Several phytochemical nanoformulations, such as paclitaxel (Abraxane ), irinotecan (Onivyde ), vinorelbine (NanoVNB ), vincristine (Marqibo ), and docetaxel (DoceAqualip ), are already FDA-approved for cancer therapy (Dhupal and Chowdhury, 2020), while multiple curcumin-, camptothecin-, ursolic acid-, mangiferin-, and quercetin-based platforms are undergoing clinical evaluation in liposomal, polymeric, micellar, and plant-derived nanocarriers (Devan et al., 2023