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Therefore, the laboratories of Dr

These findings indicate that early administration of metformin can mitigate OA-related pain in the MIA-induced mouse model

GSTO1 has been shown to play a significant role in the protein glutathionylation cycle exhibiting both glutathionylation and deglutathionylation activities 11,15

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Moreover, it has been shown that ROS can activate the signaling pathways of ATM, p38 MAPK or JNK

This process, which could be stimulated under conditions of stress, envisages a chloroplastic sequence of reactions involving H 2 O 2 -triggered S -glutathionylation of diverse available protein cysteine residues, followed by regeneration of the free cysteines by glutathione-dependent GRX (Zaffagnini et al., 2012)