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103 In one randomized clinical trial in 70 volunteers with chronic tinnitus, both 3 mg of melatonin daily and a standard dose of sertraline (Zoloft) (an antidepressant medication) for three months reduced tinnitus severity, but melatonin was more effective

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This reduces the likelihood of tissue damage and the formation of scar tissue

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Mixing them in a single solution for an extended period could lead to degradation, precipitation, or unforeseen chemical reactions that reduce their efficacy