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In terms of concomitant cardiac medications, the two arms were well balanced (statins [95% of participants], angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, anti-platelet, anti-coagulation, diabetes medications, calcium channel blockers, diuretics, anti-anginal, and nonsteroidal anti-inflammatory drugsNSAIDs), though the placebo arm had more participants on beta-blockers (49% vs 33%) and fewer participants on alpha-blockers (7% vs 12%)

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According to the specific oxidation position, the 12/15-LOX is in charge of catalyzing AA to 12-/15- hydroperoxyeicosatetraenoic acid (12-/15-HpETE) (Snodgrass and Brune, 2019)

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This is why glutathione appears in so many skin brightening protocols across LA dermatology and med spa practices

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