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Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide

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Studies have combined auranofin with cisplatin and ATR/AKT inhibitors to selectively elevate ROS levels in cancer cells and induce oxidative DNA damage [221,222,223] (Table 4)