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For example, in mouse embryonic stem cells, excess 2-OG maintains pluripotency dependent on the 2-OG/succinate ratio by increasing TET and KDM activity 45

Zakrzewska E, Zegan M, Michota-Katulska E (2015) Dietary recommendations in hypothyroidism with coexistence of Hashimotos disease

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These compounds work through independent mechanisms, meaning they can potentially be used together under physician supervision without pharmacological conflict

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Step-by-step: 1) Collect genetics and baseline labs