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doi: 10.1158/1541-7786.MCR-19-0691 63 YangL.XiongJ.LiuY.LiuY.WangX.SiY.et al

Effective treatment of cobalamin deficiency with oral cobalamin

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While in-vitro static models are commonly employed to evaluate the digestibility of various food constituents, they simplify gastro-intestinal physiology and do not accurately replicate the dynamic facets of digestion, specifically fluid dynamics and mechanical forces that take place in a series of solid beakers with constant stirring

While the largest percentage of intracellular iron is tightly bound to or incorporated into proteins as a cofactor or for storage, small portion of intracellular iron resides in the cytosol and intracellular organelles (e.g., lysosomes) and constitutes a redox-active liable iron pool, which regulates programmed cell death including ferroptosis 42