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Many animal studies have reported that glutathione exerts an agonistic effect on NMDA receptors.8791 However, in the presence of uncontrolled and persistent chronic oxidative stress, glutathione level is decreased and leads to NMDA receptor dysfunction.9293 Deficits in glutathione level are associated with neurological deficits in various neuropsychiatric diseases.94 Glutathione regulates redox-sensitive sites such as the NMDA receptor

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Thus, brain iron modulates A production by regulating APP expression and BACE1/-secretase activity

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This process, known as aerobic glycolysis or the Warburg effect, was initially described in cancer cells

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