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therefore, investigators focused on the development and safety assessment of biotherapeutics should make greater efforts to minimize patient risk, which is closely related to immunogenic potential

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Malecic N., Young H

(1997) reported that PD patients who received long-term levodopa treatment had elevated plasma bilirubin levels, showing a protective effect, whereas in most studies, treatment of PD patients was not recorded, making it impossible to adjust for drug effects, thus leading to bias in cross-sectional comparisons (Songsomboon et al., 2020)