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Artesunate protects LPS-induced acute lung injury by inhibiting TLR4 expression and inducing Nrf2 activation

Unfortunately, VEGF can also be detrimental because its overexpression can cause inflammation in the nervous system, which in turn can lead to BBB leakage, promote the production of pro-inflammatory cytokines and the occurrence of neurodegeneration (Claire and Larrive 2017

The precise origins of these diseases remain unknown but oxidative damage, impaired proteosis and inflammation are believed to be causal elements in disease development