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Sessions last 15 to 30 minutes, and we recommend 4 to 8 sessions for optimal results

High-dose thiamine (6001,800 mg/day) has shown promise in improving fatigue and pain in FM, likely by enhancing mitochondrial function and reducing oxidative stress (25)

Similarly, Longo and Matson (2014) have highlighted the potential of fasting regimens to enhance cellular stress resistance mechanisms 9,11

These impacts are described further in section V.K.6.b

Animal models All experimental protocols were approved by the Ethics Committee at the University of Zagreb School of Medicine

Another important aspect of this study is that the downregulation of mGluR8 in neuroblastoma SH-SY5Y could be important to study the mechanism of chemoresistance to the treatment with a chemotherapeutic agent