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Patients' health status was quantified using the Chronic Fatigue Questionnaire at four different time points: Before treatment, and 1, 3 and 6 months after the initiation of treatment

Studies that describe alterations in the functional connectivity of the cerebral networks, particularly within the networks that involve the amygdala and insular cortex, can better explain the role of brain anomalies in CVS.41 In a case-control study, patients with CVS showed increased functional integrity of salience intrinsic connectivity to the middle/posterior insula, a key region of the brain for nausea and viscerosensory processing.41 It is possible that this neuronal hyperexcitability and a lower threshold for triggering specific patterns within the CNS predispose to the triggering of stereotypic vomiting episodes in CVS

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An ODT formulation of vardenafil has been released [406]

doi: 10.1152/ajpheart.00295.2014 109 SuzukiTHeaneyLMBhandariSSJonesDJLNgLL