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In neurodegenerative models, oral or intraperitoneal doses of 100-250 mg/kg have shown significant antioxidative and anti-aggregation effects (158,159)

Understanding the evidence base, bioavailability limitations, and genetic factors influencing liver metabolism can support more informed decisions and meaningful conversations with qualified healthcare providers

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FDA Label Nordimet is indicated for the treatment of: - active rheumatoid arthritis in adult patients, - polyarthritic forms of severe, active juvenile idiopathic arthritis (JIA), when the response to nonsteroidal anti-inflammatory drugs (NSAIDs) has been inadequate, - severe recalcitrant disabling psoriasis, which is not adequately responsive to other forms of therapy such as phototherapy, psoralens and ultraviolet A (PUVA), and retinoids, and severe psoriatic arthritis in adult patients, - induction of remission in moderate steroid-dependent Crohn's disease in adult patients, in combination with corticosteroids and for maintenance of remission, as monotherapy, in patients who have responded to methotrexate