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doi: 10.1016/j.joca.2014.12.019

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They interfere with testosterone production, impair sperm quality, and even disrupt hormone signaling in the brain (through the hypothalamic-pituitary-gonadal axis)

IGF-1/IGF-1R induces differentiation rather than proliferation when the cells do not express or underexpress insulin receptor substrate-1 (IRS-1), a docking protein for both IGF-1R and the insulin receptor that is known to send a mitogenic, anti-apoptotic and anti-differentiation signal 35,36