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PCR amplification occurs in each droplet, and the proportion of PCR-positive droplets in the original sample is then determined through analysis

The degradation of HIF-1 in normoxia occurs via the ubiquitinproteasome pathway, but HIF-1 remains stable and retains its functionality regardless of the presence of oxygen [18]

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These cells demonstrated persistence within the tumor cavity and a favorable safety profile (absence of systemic inflammation or anti-CAR antibody responses, and no dose-limiting toxicities), and achieved transient disease stabilization in 3 out of 4 patients (172), providing initial evidence for MMP-targeted therapies

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