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In addition, metformin activated p-AMPK and promoted the translocation of Pink1 from the cytoplasm to mitochondria, thereby promoting the occurrence of mitophagy in HK-2 cells under HG/HFA ambience (141)

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For example, in a mouse model, low molecular weight AO (e.g., dimer and trimer) can significantly inhibit the long-term enhancement of hippocampal neurons and damage the spatial memory function

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