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J Pharm Pharmacol 67:673684 Repka MA, Battu SK, Upadhye SB, Thumma S, Crowley MM, Zhang F, Martin C, McGinity JW (2007) Pharmaceutical applications of hot-melt extrusion: part II

GSH effectively prevented TGF/SMAD signalling activation by LOsG (Fig

Delivering therapeutic agents to their target sites presents several challenges, including poor bioavailability, in vivo instability, low solubility, limited absorption, target-specific delivery difficulties, and suboptimal therapeutic efficacy

Sources Said HM

introduced a patient-derived breast cancer-on-chip model designed to emulate key features of the human tumor microenvironment while enabling personalized assessment of immunotherapy efficacy and safety (213)