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Regarding the structures of Pfu SAHH and Mma SAHH with their preferred substrates inosine or SIH, the oxygen attached to C6 seems to form additional hydrogen bonds with the carbonyl oxygen atoms of Asp348 ( Pfu SAHH) or Asp362 ( Mma SAHH) in the main chains

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The principles are backed up in tons of studies that generally have these findings: Carb-specific gut transporters can be trained in a very short time The sensation of "fullness" can be trained rapidly However, there are no set protocols, and the studies usually end with "do what you're going to do on race day." I think that's falling a bit short, though

5 September 2023

Mann DM, Esiri MM (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Downs syndrome