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In the brain, L-carnitine and acetyl-L-carnitine have important roles in cerebral bioenergetics and in neuroprotection through a variety of mechanisms including their antioxidant properties and in the modulation and promotion of synaptic neurotransmission, most notably cholinergic neurotransmission

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l-Carnitine shuttles fatty acids across the mitochondria membrane where they are metabolized and promote the Krebs cycle

ALCAR has an additional acetyl group, which changes its chemical structure and facilitates its crossing of the blood-brain barrier

Metabolic phenotypes are biochemical signatures that reflect an individuals unique metabolism and result from the interplay of ones genetic background, environment, microbiome, co-occurring conditions, and diet (25)