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All factors listed below (compiled from Routray & Orsat, 2012

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In the 1950s, the discovery of the Cori cycle revealed the biochemical pathway by which lactate is converted back to glucose in the liver, enhancing our understanding of glucose metabolism in conditions such as diabetes

10.1021/acsabm.0c00707 165 YangY.FanY.ZhangH.ZhangQ.ZhaoY.XiaoZ.et al (2021)

Once it happens, the methionine residue has permanently changed, and the peptide may no longer function as intended

However, after MRP1 depletion, these effects were observed already at the lowest MeHg dose (0.03 M), which is in the range of a physiological MeHg (6 g/L) concentration