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Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, Asraf O, Martino C, Nejman D, et al

IL-23 is a pivotal proinflammatory cytokine whose elevated expression enhances the inflammatory milieu and promotes the release of IL-17 A and IL-22 by Th17 and T cells, thereby establishing a positive feedback loop that accelerates psoriatic lesion development [6, 57, 58].] In imiquimod (IMQ)-induced murine models of psoriasis, CGRP expression in the dorsal root ganglia is rapidly upregulated following IMQ application and is closely associated with characteristic psoriatic inflammation [49, 54, 59]

Where specific studies are referenced, the exposure metric used (e.g., Cmax, trough, AUC, cumulative dose) is described in the corresponding manuscript text

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