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Spadaro, D

JAMA Oncol 4:930937 Doti N, Mardirossian M, Sandomenico A, Ruvo M, Caporale A (2021) Recent applications of retro-inverso peptides

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These molecules create what can be likened to cellular rust, similar to the rusting of iron when exposed to harsh environmental conditions

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It was originally isolated in 1977 from the cerebral venous blood of rabbits and has since been found to be present in small amounts in human brains and plasma, with higher concentrations later in the day.3 4 It, or a similar substance, is also present at higher concentrations in human breast milk.5 Because DSIP can cross the blood-brain barrier and is easily absorbed via the gut (unusual for a peptide), some researchers have hypothesized that it may facilitate post-feeding sleep tendencies among newborns, though it remains unclear whether DSIP truly has a hand in neonate sleep-wake cycles.4 5 6 Its mechanism of action is likewise unclear, but it may have something to do with endocrine regulation