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In a clinical study involving patients with refractory SLEdefined as those with persistent disease activity despite high-dose glucocorticoids and/or cytotoxic drugsthe combination of Low-dose IL-2 (100 WIU, 35 days/month) and rapamycin(0.5 mg every other day) demonstrated synergistic effects (272)

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Additionally, clinical trials evaluating tailored behavioral and pharmacologic cessation interventions for patients with liver disease are essential to inform evidence-based guidelines

The lack of standard diagnostic criteria for HT makes the diagnosis process subjective and does not cover the entire spectrum of the disease

However, individuals with Wilsons disease or copper metabolism disorders should exercise extreme caution

S2CID 43919271