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Enhanced mitochondrial function during fasting further supports oxidative stress reduction by lowering free radical production [29, 32]

Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

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The biologically active form of vitamin D, 1,25(OH) 2 D, has been shown to improve insulin sensitivity by enhancing the expression of insulin receptors and activating PPAR- (59)

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In addition, Bifidobacterium was increased in patients with active UC, and probiotics should be used with caution in active UC [150]