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Methods: We developed a biomimetic autophagy degradation peptide (MNP-PDL1) using the lysosomal autophagy system in conjunction with biomimetic membrane technology, which consists of a PD-L1-binding sequence, a PEG3 linker, and a target lysosomal chaperone protein recognition sequence (CIP), which can localize the target protein, PD-L1, to the lysosome for degradation

[27] Prednisolone gave a small reduction in mortality at 28 days but this did not reach significance, and there were no improvements in outcomes at 90 days or 1 year

H., Doost, A

PMID: 40494050 Brain Behav A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm

113,644 Astrocyte-selective expression of PD related A53T mutant -synuclein causes severe downregulation of glutamate transporters expression, resulting in neuronal damage, aberrant microgliosis and paralysis