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The dose of 370 mg/kg bw per day that resulted in no adverse effects is more than 1 000 000 times the daily per capita intake ("eaters only") of 0.1 g/kg bw from its use as a flavouring agent in Europe and the USA (Table 2)

The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot

PMID 15264254

It also activates a considerable subset of stress-related responsive genes

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(2005) Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations