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This review provides a comprehensive overview of the clinical features, pathophysiology, prognosis, epidemiology, histopathological characteristics, genetic and immunological mechanisms, as well as current treatments and therapeutic approaches, thereby offering the latest insights into this complex disease

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In CMT4B3 fibroblasts, Myo-Ins did not improve any respiratory parameter, consistent with the requirement for intact mitochondrial function and PIP signalling to support Myo-Insmediated enhancement of mitochondrial plasticity