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10.1016/j.cjca.2021.02.009 199 TeringovaE.TousekP

Under conditions of metabolic stress, such as hypoxia, glucose deprivation, and low serum, ACSS2 enzyme can promote malignant cell growth and survival in some solid tumors through the production of acetyl-CoA, which is further incorporated into metabolic pathways or acts as an epigenetic modulator in the activation of protein acetylation [74]

Avoidance of x-ray therapy has also been advocated for some groups with hereditary skin cancer syndromes, such as those with epidermodysplasia verruciformis.[158] However, XP patients with unresectable skin cancers or internal cancers, such as spinal cord astrocytoma or glioblastomas of the brain, have been treated successfully with standard therapeutic doses of x-ray radiation.[53] Some experts recommend dermatologic evaluation every 6 months and ophthalmologic evaluation at least annually in these high-risk populations