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Furthermore, IL-6 stimulates angiogenesis through the upregulation of VEGF, further supporting tumor growth and metastasis [133]

10.1167/iovs.08-3013 300

Yendamuri S, Vaporciyan AA, Zaidi T, Feng L, Fernandez R, Bekele NB, Hofstetter WL, Jiang F, Mehran RJ, Rice DC, Spitz MR, Swisher SG , Walsh GL, Roth JA, Katz RL

Oncogene 27 , 39443956 (2008)

3 Overview of antioxidative and other molecular mechanisms through which Se influences male fertility As previously mentioned, certain amounts of oxidative stress and ROS are necessary for normal sperm maturation, motility, activation, and fertilizing ability (18, 94, 118, 141, 142)