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However, the PDMS block was fabricated to minimize its footprint, implants were retrieved cleanly after animal sacrifice, and measurements were made in regions where the epineurium appeared intact (even if thickened), suggesting that such impacts were unlikely to be substantial

PMC 201508

Further investigation in this area could provide the basis for chronotherapeutic approaches in stroke and identify novel strategies to protect the BBB through circadian regulation

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The remaining 2 of 12 patients rated their success at 80%, with most symptoms resolved but about 20% of their symptoms lingering