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95,96 HDAC3-mediated deacetylation of ENO2 at K394 leads to its activation and enhancement of glycolysis, which finally results in the metastasis of pancreatic ductal adenocarcinoma (PDAC)

Frias et al., Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial, Lancet Lond