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In conclusion, this study provides strong evidence that curcumin exerts its anticancer effects in CRC by modulating the miR-134-5p/CDCA3/CDK1 axis, thereby suppressing tumor cell proliferation and invasion and promoting apoptosis ( 3.1.6 The Wnt/-catenin pathway The Wnt signaling pathways play a significant role in cancer development by modulating various processes such as cancer cell growth, differentiation, programmed cell death, cell cycle advancement, adhesion, and the formation of blood vessels ( in vitro experiments were carried out to determine if CUR affects this signaling or not ( in vivo , and analysis revealed that this effect was primarily due to the suppression of cell proliferation, rather than the induction of apoptosis

HGF II, however, only engages c-MET II through the interaction between HGF-SPH and c-MET-SEMA

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