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Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

pluvialis cells (Fig

Unlike Phase 1, which relies primarily on enzyme activity, Phase 2 conjugation requires an adequate and ongoing supply of specific substrates to safely neutralize activated metabolites

In addition to cytoskeletal dynamics influencing FBP production via aldolase regulation, another trigger for increased glycolysis might be an elevated glucose uptake during cell migration 60