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Lpez IP, Pieiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG

A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection

molecules involved in the inflammatory reaction also associated with Covid-19and in a mechanism called protein glutathionylation

Gpx8 knockout in mice severely exacerbated DSS-colitis and reduced gut microbiome diversity ( Gpx8 / mice post-DSS treatment expressed higher levels of pro-inflammtory cytokines (IL-1 and IL-6) and adoptive transfer of Gpx8 -deficient macrophages into mice prior to DSS treatment resulted in an exacerbated colitis phenotype indicating a protective role for GPx8 in macrophages during experimental colitis ( Gpx8 / mice was found to be dependent on its action on caspase-11

3.1.3.1 Cardiac function and cardiac nerve damage LPS, a key component of Gram-negative bacterial cell walls, induces cardiac dysfunction by disrupting myocardial electrical activity and neural regulation, with the magnitude of its effects modulated by baseline disease status, sex differences, and individual adaptive responses

doi: 10.1016/j.lfs.2024.122979 105 HeQLiGZhaoJZhuHMoHXiongZet al