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Inhibition of IDO by administering fludarabine and cyclophosphamide can restore the activity of CD19-specific CAR-T cells against IDO-positive lymphoma in vivo , suggesting that IDO is a potential therapeutic target for enhancing the clinical activity of CAR-T therapy (150, 151) ( Figure 1 )

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[DOI] [PMC free article] [PubMed] [Google Scholar] Sperner-Unterweger B, Whitworth A, Kemmler G, Hilbe W, Thaler J, Weiss G, Fleischhacker WW

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