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Circulatory & nerve health

& Monnier, M

A change in pH changes the protonation pattern and can, in extreme cases, result in protein denaturation

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For instance, the pathogenic V122I variant of the protein transthyretin can induce cardiomyopathy due to destabilization of the transthyretin quaternary structure, i.e., the tetramer-folded monomer equilibrium, and an increased rate of tetramer dissociation [73]