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Key Points One-carbon metabolism integrates cellular nutrient status by cycling carbon units from amino acid inputs to generate diverse outputs, including redox maintenance and cellular biosynthesis

The acetyl group provides a plausible protective mechanism

Branchedchain ketoacids secreted by glioblastoma cells via MCT 1 modulate macrophage phenotype

From this perspective, it is interesting to note that we recently reported that transferrin plays an important role in both high dietary iron-induced liver fibrosis and carbon tetrachloride (CCl 4 )-induced liver fibrosis in mice, and inhibiting ferroptosis potently prevented these effects