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In NCOA4 knockout cells, the content of Fe2+ is reduced, which leads to the inhibition of ferroptosis

Simunkova M, Barbierikova Z, Jomova K, Hudecova L, Lauro P, Alwasel SH, et al

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doi: 10.3390/molecules26164998 51 ElhawaryEAMoussaAYSingabANB

However, in both models, cancer cell growth was rescued under cystine-free with GSH-supplemented conditions (Extended Data Fig

It has been suggested that the function of this gate is to control access of H 2 O 2 to the haemin active sites [Dominguez, 2010]