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Hypertension, an increased risk of bleeding, and gastrointestinal perforation are adverse effects associated with bevacizumab treatment (Wang 2013

mTORC1 activation leads to LIPIN-1 phosphorylation and inactivation, followed by derepression of SREBP and upregulation of lipid biosynthesis

This issue is addressed in the following section

Funding This work was supported by Guizhou Provincial Science and Technology Projects (2018-1102)

The elevated antioxidant capacity driven by persistent NRF2 activation and enhanced glutathione (GSH) and thioredoxin (TRX) systems enables cancer cells to withstand endogenous oxidative stress and promotes metastatic behavior