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10.1038/cdd.2008.78 Cell Death Differ

One of the few meta-analyses Ive read that uncategorically reported a positive outcome stated that acetylcarnitine was as effective as antidepressants and had fewer adverse effects: Acetyl-L-supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects. Help for Neurological Disorders Both L-carnitine and acetylcarnitine are also being studied in neurological disorders

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Burri P, Djonov V, Aebersold DM, Lindel K, Studer U, Altermatt HJ, et al

Tirzepatide causes gastrointestinal symptoms including nausea, vomiting, diarrhea, and constipation in a substantial percentage of users, particularly during dose escalation phases