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These observations were further confirmed by histological analysis, indicating a worse liver appearance in transgenic mice challenged with APAP, characterized by the complete loss of lobular structure (Fig

Since the S129p site is adjacent to the DEF/YxP motif, we speculate that elevated S129p levels under pathological conditions may induce local conformational changes that modulate the interaction with H2a-H2b, thereby interfering with chromatin regulation

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Focus on a balanced diet that includes: Proteins: lean type, such as chicken, fish, tofu Grains: whole grain type, such as brown rice, quinoa Fructo-and vegetal intake Healthy fats: avocadoes, nuts, olive oil Eat fewer refined sugars and prepared foods Physical Activity Furthermore, it's thought that physical activity promotes the creation of fat and may improve insulin function