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Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene

doi: 10.3389/fcell.2025.1623959 Received 06 May 2025 Accepted 04 August 2025 Published 20 August 2025 Volume 13 - 2025 Edited by Valerie Kouskoff, The University of Manchester, United Kingdom Reviewed by Soumya Ranjan Jena, Ravenshaw University, India Vinod Reddy Lekkala, University of California, San Francisco, United States Updates Copyright 2025 Feng and He

This induction significantly reduces iron death markers, including PTGS2 and ACSL4, in NPCs by up to 70%

It boosts glutathione production, which supports the livers detoxification processes and protects against damage from toxins, alcohol and medications like acetaminophen

Side effects are rare and usually mild, such as slight irritation at the IV site, nausea, or headache

These studies should measure fertility-related endpoints and include diverse populations