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In the adrenal gland, mutations such as G151R, T158A, or L168R in the human GIRK4 channel (encoded by KCNJ5 ) result in aldosterone-producing adenomas (APA) ( Numerous modulators that influence the activity of GIRK channels have been identified, including sodium, ethanol, and phosphorylation by protein kinase A (PKA) and protein kinase C (PKC)

Pancreaticoduodenectomy for peri-ampullary neoplasia leads to specific micronutrient deficiencies

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Incidentally, this line of work, culminating in the article by Ferreri et al