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These findings provide multiomic evidence that clarifies the molecular heterogeneity in PD and highlights gut microbiota-driven dysfunction as a key contributor to both the iRBD and RBD-PD subtypes

Within microbial communities, riboflavin is produced by prototrophic species (i.e., species that are equipped with a complete and functional pathway for de novo biosynthesis of certain micronutrients) to cross-feed auxotrophic species (i.e., species that lack the corresponding biosynthesis pathways) in exchange for other metabolites, mostly nutrients or energy 206

an apoptosis-specific marker, cleaved Caspase 3

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