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But it is most effective when it reaches and enters the blood stream

Enhanced oxidative stress may also impair endothelial function, leading to diminished endothelium-dependent vasorelaxation and heightened vascular contractility

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In particular, inefficient lipid clearance can lead to tissue accumulation and potential toxicity, making the ability to predict clearance behavior a key objective in the development of next-generation LNPs

doi: 10.3390/nu16132166 64