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however, there are limited human studies

[1] Cell Line:C2C12 cells Concentration:0-5 M Incubation Time:24 h Result:Increased the levels of pyruvate dehydrogenase kinase 4 (Pdk4) expression and induced mitochondrial biogenesis in proliferating C2C12 cells

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"It doesn't necessarily mean the supplement suddenly becomes dangerous the next day, but it may not be as effective after that point," says Reshma Kapadia Patel, Pharm.D