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16 Fibromyalgia and other related conditions Chronic fatigue syndrome (CFS) While fibromyalgia and CFS are interrelated conditions, they have distinct characteristics

The latter category revealed strong upregulation of genes associated with ISR, including amino acid synthesis and one-carbon metabolism ( Mthfd2 , Pycr1 , Asns , Psat1 ), tRNA charging, amino acid transporters ( Slc7a1 , Slc1a4 , Slc3a2 ) and various stress-response genes ( Fgf21 , Gdf15 , Ddit3 , Trib3 , Atf5 , Atf6 ) (Fig

Furthermore, elevated levels of vitamin C can enhance immune responses beyond physiological needs, offering additional protection against stress (Trichet, 2010)