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For bone surface erosion, we could see that SP@M could considerably inhibit bone erosion in the ankle and toe joints of CIA mice, which is even better than that in the MTX group

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212,213 Under KD conditions, the reduction of brain glucose utilization and glycolytic ATP production may induce potassium channels that are sensitive to ATP opening, which leads to the hyperpolarization of the neuronal membrane, 214 consequently reducing the electrical excitability of the brain and increasing the seizure threshold

Plasma MDA (a lipid peroxidation marker) should decrease or remain stable despite ongoing weight loss if MDA rises while glutathione increases, oxidative stress exceeds antioxidant capacity and dosing adjustments are needed

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