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For example, Brenton et al

Thus, it needs to be cleared out quickly to prevent cell and DNA damage, which can lead to cancerous mutations.[ref] Two well-studied genetic variants have different ways of reaching the same endpoint: ~ an alcohol dehydrogenase (ADH1B) variant that speeds up the conversion to acetaldehyde, thus creating a buildup of acetaldehyde ~ an acetaldehyde dehydrogenase (ALDH2) variant that slows down the conversion from acetaldehyde to acetic acid, again creating a buildup of acetaldehyde

Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation

10.3389/fneur.2019.01245 208 JaggarM.ReaK.SpichakS.DinanT

doi: 10.3109/10717544.2014.907372 231

Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages