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Rotating sites systematically allows any irritation to resolve before returning to a previously used location

For less distinct drug-induced adverse effects, however, the number of replicates should be increased

10.1038/s41579-020-00460-0 112 MouriesJ.BresciaP.SilvestriA.SpadoniI.SorribasM.WiestR.et al (2019)

This theoretical framework, enriched with the Italian Territorialist School knowledge, was tested through the development of a methodology designed to delineate the CRFS using the territoriality concepts as proposed by geographic scholarship also in relation to food systems

This type of pigmentation occurs as the skin heals from trauma, with melanocytes often producing excess melanin in the affected area